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A New Approach for the Treatment of Inflammatory Arthritis

In collaboration with researchers at the University of Minnesota, researchers at the University of Minnesota have found that non-invasive stimulation of the spleen with ultrasound daily in rats with inflammatory arthritis significantly reduces joint swelling compared with untreated arthritic rats. The study is the first step in developing new treatment options for more than one million people in the United States, currently suffering from rheumatoid arthritis.

This study Natural communication Conducted a preliminary human clinical trial in Minnesota.

"What we found in mouse studies is that the ultrasound stimulation of the spleen outside the body can actually reduce the inflammatory response," said Daniel Zachs, a biomedical engineering researcher and the first author of the study. The University of Minnesota's College of Science and Engineering. "We hope that this type of non-invasive treatment will someday complement current therapies for patients with rheumatoid arthritis."

Inflammatory arthritis is an autoimmune disease in which the body's immune system attacks bacteria, viruses and other foreign bodies as well as healthy tissue. This reaction can cause pain, stiffness and joint damage. Current therapies generally include medicines with a variety of side effects.

The researchers involved in this new study targeted inflammation-induced arthritis in experimental mice and then spleens with ultrasound stimulation for 7 days post-injection. Some mice received treatment when arthritis became apparent on the third day. Ultrasonically treated rats showed significantly less joint swelling than rats not receiving ultrasound stimulation.

"Using non-invasive ultrasonic stimulation of the spleen to treat progressive disease, such as inflammatory arthritis, seemed like the idea," said Dr. Hubert Lim, a senior author of the study and an associate professor of biomedical engineering at the University of Minnesota Medical School. College of Engineering and Medical Science. "We were pleasantly surprised at how our results and the separate research independently conducted by GE Research and the Feinstein Institute for Medical Research resulted in the same results. Natural communicationWe have shown results consistent with our research. "

In addition to focusing on reducing inflammation, the researchers studied specific types of leukocytes needed to reduce inflammation. The researchers found that leukocytes, called T cells and B cells, are involved in reducing the severity of arthritis by analyzing gene expression and eliminating specific types of white blood cells.

"Rheumatoid arthritis can be devastating if not actively treated," said Dr. Bryce Binstadt, senior author of the study, and associate professor of pediatrics and pediatric rheumatology at the University of Minnesota School of Medicine. . "The idea is that we can improve the treatment of arthritis by using ultrasound rather than additional drugs," he says. "This study shows us the progress we can make when doctors and engineers work together to solve problems."


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