Scientists have made a major discovery that illuminates a new, descriptive light on the link between obesity and cancer. Their research confirms why the body 's immune surveillance system, led by Natural Killer cells fighting cancer, stammers and fails to become a fat fat. It also describes a possible route to a new therapeutic strategy in which the "fat-clogged" Natural Killer cells are molecularly reprogrammed and reactivated.
More than 1.9 billion people are overweight and obese (more than one-third of the adult population), and over one-third of the adult population is an adult, putting great health and economic burdens on society. Type 2 diabetes, cardiovascular disease and various infections. Also, up to 50% of certain cancers are caused by obesity.
However, until now there has been little known the effect of obesity on immune surveillance.
The changes were led by research associate professor of immunology at Trinity College Dublin, Lydia Lynch, Harvard Medical School and Brigham Women's Hospital, USA. This study has been published in international journals. Natural immunology.
Studies of human natural killer cells and model organism rats have shown that scientists first discovered that the molecular machinery of natural killer cells is clogged by excess fat in obese individuals. This clogging does not prevent Natural Killer cells from recognizing tumor cells, but it can prevent them from killing them.
Subsequently, further investigation revealed precisely the specific metabolic process inhibited in fat-stained natural killer cells, and by promising to develop stem cell treatments, scientists could reprogram these cells and restore the cancer fighting ability Metabolism is needed.
Professor Lynch said that despite the heightened awareness of the public, the ongoing epidemic of obesity and related diseases suggests that obesity needs to develop new strategies to understand the pathways that can cause cancer and other diseases, Urgent tasks are being raised.
"Our results highlight the immune metabolic pathway as a promising target for reversing immune deficiency in obesity, suggesting that metabolic re-programs of natural killer cells can initiate anticancer activity and improve outcome."