For the time being, scientists in this area have thought that Alzheimer's disease of dementia can be an epidemic. Researchers still do not understand the exact process of such an infection. But new research has shown that there is a real connection between Alzheimer's and bacterial infections.
A researcher led by microbiologist Jan Potempa of the University of Louisville in the United States found Porphyromonas gingivalis, a bacterium responsible for dental and gum disease in the brain of a dead Alzheimer's patient.
As a result, the researchers found that oral infections actually lead to bacterial colonization of the brain. In the brain they increased the production of antibiotic beta-amyloid, which is associated with Alzheimer's.
At the same time, researchers found gingipain in the brain. These are toxic enzymes formed by bacteria. They also found it in the brain of a deceased person who has never been diagnosed with Alzheimer's disease. Alzheimer 's can break up with them if they lived longer. Researchers say it is not the case that Alzheimer's disease causes tooth and gum disease, but it's the other way around.
Cortexyme, who participated in the study, developed a compound called COR388, which reduced the number of bacteria infected with Porphyromonas gingivalis and the production of beta-amyloid in mouse experiments. Researchers, however, can not confirm the effect of COR388 in the fight against Alzheimer's disease.
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