What makes a healthy diet healthy?
Age itself is a risk for many diseases, such as neurodegenerative diseases such as cancer, heart disease and Alzheimer's disease. Exercise and a healthy diet are often recommended as prevention. However, it is still considered insufficient in many areas as to why a healthy diet is actually healthy can extend its life expectancy. The international team has taken a huge step to solve this puzzle.
International researchers at the University of Greifswald have been able to use state-of-the-art techniques to develop methods for measuring changes in protein. Modified proteins play an important role in the development of serious diseases and healthy aging processes. By measuring these changes, the team finally wants to unravel the mystery of healthy aging. The findings are published in the recent journal Nature Communications.
90 years of aging research
In the early 1930s, researchers at Rat recognized that a limited calorie intake would increase the average life expectancy of mammals. Today, as well as the number of calories, the food composition on the positive side of life and health status is also condemned. However, the fundamental mechanism by which these effects are present is not yet understood at the molecular level. Over the past decade, the rapid development of quantitative mass spectrometry has led to numerous studies of aging processes in which amino acid lysine has been identified as a major factor in healthy aging.
How does amino acid lysine relate to aging?
Lysine is an amino acid in proteins. It acts as a building block for many other proteins and is found, for example, in enzymes, plasma, antibodies, hormones, bones, skin, tendons and muscle tissue. Since the body can not produce lysine itself, amino acids must be absorbed through the diet. Researchers report that protein changes occur in diseases such as cancer and neurodegenerative diseases. These changes especially affect lysine. In the course of the disease, this amino acid has a chemical modification that changes the basic function of the whole protein. According to the team, the onset of serious illness is being promoted.
New ways to measure protein changes
"Until now, it was not possible to determine exactly how much of this strain was transformed into lysine in all of the cells in the cell. Michael Lammers in press release on study results. This is possible with the newly developed method. As a result, it is possible to find sites that are highly relevant and have changed.
Are pills healthy in aging?
"We can now find promising target proteins for the therapeutic approach," concluded the professor. Researchers believe it is even possible to mimic the positive effects of a healthy diet that does not require strict control of diet. (VB)