Thursday , August 5 2021

Inappropriate and inconsistent anaphylaxis due to unknown causes: Med e-News



A new Canadian study led by a team of researchers at McGill University Health Center (RI-MUHC) reveals anaphylaxis due to an unknown trigger (AUT) that causes an unpredictable and potentially fatal allergic reaction. Almost unknown.

This study Journal of Allergy and Clinical Immunology: Practice, Anapelaxis showed almost 4,000 anaphylaxis in Canada's emergency rooms from 2011 to 2018. Common causes of anaphylaxis include food, drugs, insect stings, latex, and exercise, but some episodes have no obvious cause. In the case of food hypersensitivity, avoiding induced food is a core principle of management. However, in the case of AUT, the possibility of suddenly life-threatening anaphylaxis artifacts can occur at any time.

"In our study, 7.5% of an anaphylactic patients were due to an unknown cause and we found that the treatment and follow-up of AUT was inadequate and inconsistent both inside and outside the hospital," said Lead researcher Moshe Ben-McGill, -MUHC) and the pediatric allergist and immunologist Shoshan of the Montreal Children's Hospital of MUHC

"In particular, epinephrine was not used, and antihistamines were the main treatment for AUT. In our study, 46% received antihistamines before they arrived at the hospital, and 55% had antihistamines in the hospital emergency room." Ben – He is also an assistant professor of pediatrics at Shoshan McGill University.

This is the first longitudinal, large-scale study to assess the clinical characteristics, treatment and follow-up of AUT cases across Canada. This study is part of a larger national project and database called the Cross-Canada Anaphylaxis Registry (C-CARE) that tracks the proportions, triggers and management of anaphylaxis in various regions and environments throughout Canada.

Other results of the study:

  • Approximately one-fifth of AUT patients did not prescribe an epinephrine automatic syringe.
  • Adults were less likely to receive an epinephrine autologous syringe prescription than a child.
  • Only 56% of depressed patients showed allergic reactions, most of them children.
  • 38% of the patients evaluated by the allergy specialist had an allergic reaction.

Michelle Le, a medical student at McGill University, says: "People who have a low rate of allergic reactions to people who do not use epinephrine and who are allergic to it often emphasize the need for clear instructions and education programs for diagnosis and management in adults with autism. "And AllerGen trainees.

"An important part of this study is that there is a significant discrepancy in the treatment and follow-up of AUT patients who need to be addressed to ensure rapid and appropriate management of anaphylaxis."


About AllerGen NCE

AllerGen NCE Inc., an allergy, gene and environmental network (estimated 2004) is a national research network devoted to improving the quality of life of people suffering from allergies and related immune disorders. This network, sponsored by Industry Canada, through the federal Centers of Excellence (NCE) program, is held at McMaster University in Hamilton.

About MUHC Lab

The McGill University Health Center (RI-MUHC) is the world-renowned biomedical and health research center. In partnership with the Department of Medicine at McGill University, the Institute is a research division of the McGill University Health Center (MUHC), an academic health center located in Montreal, Canada. RI-MUHC supports more than 460 researchers and 1,300 research trainees at MUHC's Glenn and Montréal general hospital sites devoted to extensive baseline, clinical and health outcome studies. The institute's research facilities provide a dynamic multi-disciplinary environment that facilitates collaboration and exploits discovery to improve the health of individual patients at every lifetime. RI-MUHC is partially supported by FRQS (Fonds de Recherche du Québec-Santé). rimuh.ca.


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