Madrid, April 17 (Europa Press) –
Oral detergents containing diphenhydramine, lidocaine, and antacids significantly reduced the pain of oral ulcers in patients receiving radiation therapy for head and neck cancer. This is the result of a three-phase, randomized, double-blind, placebo-controlled clinical trial led by Robert Miller, a Mayo Clinic (US) oncologist.
In an article in the American Medical Association journal, Miller and colleagues found that pain associated with oral mucositis in 275 patients between November 2014 and May 2016 was significantly lower after mouth rinsing with doxepin and mouth rinses for placebo. They also found that doxepin and mouth rinses were well tolerated by patients.
"Our group has already published a study in 2012 that shows that oral cleansing with doxepin reduces pain associated with oral mucositis compared to placebo, but there was no large randomized study that looked at the potential benefits of magical mouthwash." Miller explains the relevance of this new study to confirm the results.
A co-author of Terence Sio recalls, "Radiation therapy can cause inflammation in the mouth to kill cells that grow quickly, like cancer cells." "Unfortunately, healthy cells in the mouth can grow disrupted and grow quickly, which can lead to discomfort during radiation therapy. We are pleased to find a proven way to cure the discomfort of this side effect." I concluded.