Tuesday , June 18 2019
Home / chile / Scientists develop a 'mini brain' model of human prion disease.

Scientists develop a 'mini brain' model of human prion disease.



Madrid, June 14 (EUROPA PRESS) –

Scientists at the US National Institutes of Health have used the first brain organism system or "mini brain" to use human skin cells to study sporadic diseases of Creutzfeldt-Jakob (CJD) 39; has been created. Fatal neurodegenerative brain pathology caused by infectious prion protein affects one in every 1 million people.

Human brain organisms are small balls of different human brain cells that are the same size as small peas in poppy. Its tissue, structure and electrical signals are similar to that of brain tissue. Because it can survive for months in a controlled environment, diseases of the nervous system can be studied over time. Cerebral organoids have been used as models for studying Zika virus infection, Alzheimer's disease and Down syndrome.

In a new study published in the journal 'Acta Neuropathologica Communications', scientists used a sample of two patients who died of two different subtypes of Creutzfeldt-Jakob disease to infect a 5-month-old brain tissue with a prion I found a way. MV1 and MV2.

The infection took about a month to identify, and scientists monitored the organoid for changes in health indicators, such as metabolism, for more than six months. At the end of the study, scientists observed that seed activity, a sign of infectious prion spread, is present in all organisms exposed to CJD samples. However, the MV1 samples were higher than the MV2 samples in infected organoids. Organisms infected with MV1 showed more damage than MV2-infected tissues.

Scientists have also observed other differences in the evolution of MV1 and MV2 infections in organisms. They plan to further explore these differences to see how other subtypes of Creutzfeldt-Jakob disease affect brain cells.

Ultimately, they hope to learn how to prevent cell damage and restore function of damaged cells by prion infection. The new system also provides an opportunity to test potential treatments for Creutzfeldt-Jakob disease in a tissue model that mimics the human brain.


Source link