Sunday , April 18 2021

The first cell map to avoid complications of pregnancy



Scientists at the Wellcome Sanger Institute, the University of Newcastle and the University of Cambridge, UK, along with Nature this week gave the most detailed cell map of the contact area between mother and future child Announced. This cytoplasmic atlas presents the key to avoiding the most common initial problems and achieving successful pregnancies without complications.

Researchers, including Spanish brothers Roser and Miquel Vento-Tormo, were able to map transcriptomes (transcribed DNA) from healthy cells collected between 6 and 14 weeks of pregnancy thanks to complex bioinformatics and genome technology.

"It was an idea to understand the mechanisms that occurred in the first trimester of pregnancy without complications, so we created a reference map of all the cells and their interactions to compare the differences that represent problems with future healthy pregnancy." Roser Vento-Tormo from the Wellcome Sanger Institute explains.

"We discovered that a gene could alter maternal immunity and allow the fetus to develop properly, Roser Vento explains.

The analysis focuses on the first pregnancy as it is an important moment in determining the survival of the fetus (and subsequently the fetus). During the first week, the embryo's fetal cells (interact with their mother's fetal cells to correct the immune response) are formed to avoid the situation of rejection.

This allows the fetus to adhere to the uterus of the decidua, the innermost layer of the pregnant uterus, which grows thicker to prefer pregnancy. It also acts as a way to feed and oxygenate the fetus during the next month.

"For the first time in history, we have been able to observe what genes are active in desquamation and placental constituent cells, so we have discovered genes that alter the maternal immune system and allow for the correct development of the fetus.

Reduced complications

The likelihood of complications during pregnancy is higher during the first week when the fetus has not yet become diseased. In fact, two out of three abortions in the first trimester occur spontaneously.

Vento made it clear that she was only committed to understanding her healthy pregnancy for a while. "But in the future, we can analyze patient samples to predict what type of changes will occur in the early years of pregnancy."

Muzlifah Haniffa, a researcher at the University of Newcastle, added, "These results will be important to better understand what happens when a pregnant woman suffers from pre-eclampsia or even miscarriages."

In the future, experts will be able to predict what kind of changes will occur early in pregnancy

This finding has an important impact on cancer research because it is known to specialists that tumor cells use similar mechanisms to evade the immune system and increase blood flow and size.

Open database

The result is a result of a tool developed jointly with Miquel Vento-Tormo of YDEVS, a Spanish software development company, and his team.

This database, named CellPhoneDB, not only predicts the most likely cell interactions but also collects information about the molecules and their interactions. According to Roser Vento, "This tool can be applied to any fabric, making it accessible to everyone with our brother Miquel."

Cellular map of the human body

As part of the Human Cell Atlas initiative, this study is part of an international consortium led by researchers from Sara Teichmann (one of the key managers of this publication) and Wellcome Sanger Institute.

"We plan to make a complete reference map of all human cells to better diagnose the disease with this plan," Vento concluded.


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