Thursday , March 30 2023

IPS stem cells transplanted into the patient's brain in Japan


It is the first product in the world to give hope to Parkinson's patients. A researcher at Kyoto University in Japan announced on Friday, November 9, that they successfully transplanted 2.4 million iPS stem cells into the left brain of patients with Parkinson's disease. & Quot; derived pluripotent stem cells & quot; or French pluripotent cells).

The surgery lasted for three hours last month. His 50s male patient survived well. He will now be under surveillance for two years. If there is no problem within six months, the doctor will implant 2.4 million additional stem cells to the right side of the patient's brain.

Pluripotent stem cells

Parkinson's disease, the second most common neurodegenerative disease of Alzheimer's disease, affects about 200,000 people in France and more than 1 million people in Europe. In France, 8,000 new cases are reported annually. According to the US Parkinson 's Disease Foundation, there are 10 million people with Parkinson' s disease in the world.

Parkinson's disease is characterized by the progressive loss of neurons in the gray nucleus of the brain, leading to a gradual decrease in motor control and the onset of other motor symptoms such as tremors and stiffness of the limbs. Currently available therapies "improve symptoms but do not slow the progression of the disease," says Parkinson's Disease Foundation.

This new treatment with healthy donor iPS stem cells provides new hope for patients. Indeed, the latter has the distinction of pluripotency: By implanting in the brain, we can develop neurons that produce dopamine, a neurotransmitter involved in athletic capacity control.

Clinical trial announcement for 7 patients

A successful essay by Japanese scientists is probably not the last thing. In July, Kyoto University announced that it will start clinical trials with seven participants aged 50 to 69. On the NHK public television channel on Friday Professor Jun Takahashi said, "I pay homage to patients for their courageous participation.

This clinical trial itself is based on experiments performed on monkeys with human-derived stem cells and reported in an article published in Nature in August 2017. According to the researchers, the transplant improved the capacity of Parkinson's disease A form of primate makes exercise. Survival of the transplanted cells by injection into the brain of the primate was observed for 2 years without the appearance of the tumor.

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