Sunday , November 28 2021

Israeli scientists design human tissue for transplantation using patient's cells – Xinhua



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Tel Aviv University in Israel has said that Israeli researchers have developed ways to manipulate human tissues for transplantation from patients' own small adipose tissue.

This method allows all tissues of the body to be produced in a personalized manner for the patient without rejection by the immune system.

Until now, immunosuppressants were needed because of the widespread use of synthetic or animal-derived substances that cause an immune response in the patient.

In tissue engineering, synthetic or biological polymers are used as extracellular materials that can support cells and make functional tissues.

So far, extracellular material, which is thought to be the most suitable for transplantation, is taken from pig tissue. In this process, all pigs' cells are removed and the rest of the cells grow into human cells.

However, the extracellular material of the pig can cause a severe immune response and reject the implant. Patients also need to take medications that sometimes suppress the immune system.

To find a solution, the researcher removed the adipose tissue from the patient in a minimally invasive procedure, separated the cells from the extracellular material, and made a custom gel for the patient.

Then, fat cells can be "reprogrammed" into pluripotent stem cells, transforming them into all cell types.

The researchers therefore succeeded in producing tissues to treat damaged heart muscle, nerve tissue in patients with Parkinson's disease, and adipose tissue for reconstructive surgery.

Because the tissue is derived from the patient, it does not cause an immune response. This technique has been successfully tested in animal and human immune cells.

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