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Genetic mutation blocking and cancer treatment: Dong-A Science


November 08, 2018 17:45


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Genes are often thought to have been determined from birth, but they also depend on lifestyle and the surrounding environment. This is called 'acquired gene expression mutation', but it has been recently pointed out as a cause of major diseases.

Professor Kim Jeong-seon and Professor Lee Young-chul of Chonnam National University said on the 8th that they discovered how to control the mutation of acquired gene expression by controlling enzyme (protein) in human body.

The researchers looked at the 'histone deacetylase' in the body. It participates in various biological actions such as death of cancer cells, angiogenesis and metastasis of tumor, differentiation and inhibition of immune cells, muscle differentiation and myocardial formation. Scientists are using this to develop a new concept of cancer drugs. However, the roles are so varied that if the function is interrupted unconditionally, toxicities will appear in the digestive system, blood cells, myocardium, and nerve cells.

Histone deacetylase is known as a type 2 histone deacetylase (type 2 enzyme), which is associated with the anticancer effect. The researchers found a protein called 'SMRT' that helped activate the type 2 enzyme and succeeded in revealing its structure. We also found a specific structure in which the SMRT protein selectively binds to type II enzymes.

The researchers hope that if further research is conducted, they will be able to develop drugs that selectively block type 2 enzymes. Professor Kim said, "In future studies, it is expected to develop new drugs that minimize side effects and increase cancer cell death and inhibit tumor angiogenesis."

The research results were also introduced in the October 13 issue of the International Journal of Nucleic Acids, an international journal in biochemistry and molecular biology.

November 08, 2018 17:45


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