There is a small expression of fear that brings you all weekend. Scientists at North Carolina State University Disease-causing Salmonella Bacteria in the United States that can resist one of the few remaining antibiotics that can be used for certain infections. Worse is that the mutation responsible for this new resistance is easily transferred to other germs, increasing the risk of some infections that can not be treated because of antibiotics.
The last antibiotic in question is a 50-year-old drug called collistin. Colistin was not the safest and most effective treatment at its heyday, and it could eventually damage the kidneys, so colistin was not beneficial to the doctor. However, because they could still kill Gram-negative bacteria resistant to several antibiotics, they emerged again as the last line of defense. This bacterium contains commonly occurring bugs. Escherichia coli As well as hospital-related infections Pseudomonas aeruginosa and Klebsiella pneumoniae.
To date, there has been no evidence of extensive resistance to cholestyin among these special super insects. But scientists have begun to discover genetic mutations that allow bacteria to resist colonization of other bacteria through free-moving DNA called plasmids. After the initial discovery of mobilized colistin resistance (MCR) genes was published in 2015, at least two, but possibly as many as eight different MCR variants were found elsewhere.
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This is very dangerous because plasmids can move between bacteria. So this MCR gene Escherichia coli For example, all other drugs are resistant. And if the strain is infecting people and getting seriously ill, there may not be a way for your doctor to treat you. Except for the recurrence of this event and the discovery of new or old drugs that can lead to the failure of the colistin, we will remain a reality with some infections, particularly infections in hospitals or other areas where super bacteria are prevalent . It can not be treated simply.
It is a nightmare scenario that physicians, including the authors of this recent study, have begun actively searching for resistance genes in the wild, particularly MCR.
The study found that an 18-year-old male patient with diarrhea from food poisoning was found and visited a doctor in 2014. After the test, the patient was sick and was suspected to be sick. Multidrug resistance Salmonella. When the team tried his sample, he found the MCR variant MCR3-1 in the plasmid.
Their work was published in the Journal of Medical Microbiology in early June.
Colistin is generally not used for treatment. Salmonella, But related Escherichia coli And other gram negative bacteria. The person's infection can still be treated with other antibiotics. However, the discovery of this particular combination Salmonella Bacteria and MCR3.1 are ominous as the first known case, according to researchers. Two weeks before his visit, he traveled to China. Chronic use of cholestin as a farm antibiotic has recently ended and has spurred the emergence of MCR. However, as you can see from this example, MCR has been internationally active in more than 20 countries, both for humans and animals.
These MCR cases can not be cured for some time (or they can cause illness at all times), but the more often they occur, the greater the likelihood that the true odor resistance and serious infection will become the new normal. Given that this event actually happened in 2014, the overall situation is likely to have worsened since then.
Everyone is saying: Have a nice weekend!