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Is there a risk of Alzheimer's disease? Exercising in the bay can be helpful.


New research suggests that even with a high risk of Alzheimer's disease, a little exercise can make time.

People with elevated levels of brain proteins called beta-amyloid have a high likelihood of developing Alzheimer's disease and later a rapid decline in brain activity, research shows.

However, scientists have reported that they can delay the onset of Alzheimer's disease through regular exercise.

"One of the earliest changes in Alzheimer's disease, people with high levels of amyloid activity," says researcher Jennifer Rabin, "the researchers say, Is a scientist who runs the Hurvitz Brain Sciences Program at the Sunnybrook Institute in Toronto.

I have not done much exercise to enjoy this protection.

According to these sources, people walking 8,300 to 8,900 steps per day significantly delayed the onset of Alzheimer's, Rabin said.

Previous studies have shown that elderly people generally live longer in their old age. But this new study suggests that physical activity is particularly protected for people with early brain Alzheimer-related changes, Dr. Howard Fillit says. He is executive director and chief scientific officer of the Alzheimer's Drug Discovery Foundation.

"This population is clinically normal, but it is different from what we had previously studied because we are seeing people with evidence of Alzheimer's in the brain," said Fillit, who is not involved in the study.

In this study, Rabin and her colleagues asked 182 participants in the Harvard Ageing Brain Study to wear a pedometer for a week to measure the normal level of physical activity. Brain scans have been used to detect levels of amyloid beta in the brain.

Beta amyloid can be a lump in the brain of a patient with Alzheimer's disease, which can destroy the brain cell function by collecting sticky plaques between neurons.

The researchers conducted an annual test to check participant brain function and track participants for seven years. Repetitive scans were also performed to see if the brain began to contract, which is a sign of progression to Alzheimer's disease.

This study found that walking people tend to stay sharper and have a tendency to slow the volume of their brain.

Notably, Fillit said, the brain benefits of exercise are independent of the benefits to heart and vascular health.

Fillit and Rabin said that physical activity is helping the brain beyond a way to prevent micro-strokes that can contribute to dementia.

Rabin said physical activity can preserve brain function by reducing inflammation, improving overall blood flow in the brain, or helping people better.

Exercise is also associated with high levels of BDNF [brain-derived neurotrophic factor]"It's the brain chemistry, the most powerful neuro-protective growth factor we know."

"It does not have to be an education at the level of the Tour de France," Fillit said. "It can only increase your heart rate by riding a treadmill or an oval."

Rabin warned that physical activity can help alleviate the amyloid-related decline in brain function, but those with high levels of beta-amyloid are not getting old and people without amyloid in their brains will not age.

But combining exercise with good heart-healthy habits such as transplantation and blood pressure control can further reduce the risk of future brain damage, Rabin added.

"If you have a choice of good life, you will be able to return to the normal aging track," Lavin said.

The results of this study are as follows: JAMA NERVE The same day was announced at the Alzheimer's Association International Conference in Los Angeles.

Additional Information

The Alzheimer's Association knows more about Alzheimer's disease prevention.

Source: Jennifer Rabin, Ph.D., Scientist, Hurvitz Brain Science Program, Sunnybrook Institute, Toronto; Howard Fillit, MD, Executive Vice President and Chief Scientist, Alzheimer 's Drug Discovery Foundation, New York City; July 16, 2019 JAMA NERVE, online

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